In contrast to MR antagonism, genetic ablation of myeloid MR in female mice significantly reduced infarct size (myeloid MR knockout, 9.4 mm3 [5.4 to 36.6]; control, 66.0 mm3 [50.0 to 81.4]; n=6 per group) after transient middle cerebral artery occlusion. This evidence concerns the gene NR3C2 and medical procedure.