MyMRKO mice are protected from ischemia-reperfusion injury in the brain, which demonstrates the importance of myeloid cells as targets for MR antagonists during ischemic stroke.9 Previous studies also indicated that female rats lack responsiveness to MR antagonists10; therefore, we tested whether genetic myeloid MR ablation was protective in females during ischemic stroke. The gene discussed is NR3C2; the disease is ischemic stroke.