Interestingly, though, male rats have been shown to metabolize eplerenone more rapidly than females, making this explanation unlikely.19 Furthermore, this hypothesis is confounded by the observation that MR antagonists have beneficial effects in females during models of cardiac remodeling and cerebral aneurysm formation.20,21,22 Taken together, the available data suggest that the sexual dimorphic actions might be due to model-specific effects rather than differential drug metabolism. This evidence concerns the gene NR3C2 and brain aneurysm.