The Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for performing preclinical stroke studies include the use of multiple models (permanent and transient occlusion) in both male and female subjects to better assess the viability of drugs for clinical translation.15 In accordance, we investigated the effects of the MR antagonist eplerenone during transient MCA occlusion in both sexes and discovered that it is protective in male but not female mice. Here, NR3C2 is linked to stroke disorder.