In fact, MR clearly has effects in other cell types within the brain and cerebrovasculature, and MR overexpression in neurons actually has been shown to have beneficial effects during cerebral ischemia.23 It is possible, then, that sex-dependent differences in the expression and regulation of neuronal MR or in the intracellular metabolism of MR agonists or antagonists could play a role in sexually dimorphic responses to MR antagonists in stroke. The gene discussed is NR3C2; the disease is stroke disorder.