Liu and colleagues8 confirmed the key role of ASK1 in myocardial ischemia–reperfusion injury by studying mice overexpressing ASK1 selectively in the heart 3 weeks after birth (to eliminate developmental effects of ASK1), which had a 2-fold increase in infarct size after 60 minutes of regional myocardial ischemia and reperfusion. Here, MAP3K5 is linked to myocardial ischemia.