NOS3 and diabetes mellitus: Finally, and potentially of significant import, bromocriptine therapy of hypertensive, insulin-resistant, arteriosclerotic rats has been shown to reduce arterial stiffness and endothelial nitric oxide synthase uncoupling,40 a phenomenon seen with diabetes that results in reduced nitric oxide generation and overproduction of reactive oxygen and nitrogen species in vessel walls that can induce prodigious damage to the vasculature.41