This assumption also is based on recently collected experimental data from a mouse model of leptin-induced aortic aneurysm, which revealed a direct local degenerative effect on the extracellular matrix attributable to locally applied leptin on the outer aortic wall surface.36 Although leptin synthesized in the plaques might have strong local effects, it is unlikely to contribute significantly to the systemic pool of leptin, determined by its synthesis in white adipocytes. The gene discussed is LEP; the disease is aortic aneurysm.