LGALS3 and hydrops fetalis: Clinical decompensation is associated with impaired renal function,2008 as is HF with preserved ejection fraction (HFpEF) versus reduced ejection fraction (HFrEF).21,22 Accordingly, a goal of the present study was to determine whether increased GAL-3 in HF is related to either the level of compensation or the underlying pathophysiology (ie, HFpEF versus HFrEF).