LGALS3 and hydrops fetalis: However, evidence also exists that GAL-3 could protect the kidney from ischemia/reperfusion32,33 and in CKD.34 Finally, it is possible that increased GAL-3 in HF reflects production by organs other than the heart and kidneys, particularly in the setting of systemic inflammation35,36,37 that can occur in both HF and CKD.38