LGALS3 and hydrops fetalis: Prior studies of plasma GAL-3 in HF have focused primarily on patients with HFrEF13,18 or on mixed populations of patients with HFrEF and HFpEF.12,14,19 No prior study has systematically compared plasma GAL-3 levels between HFpEF and HFrEF in patients with both stable and decompensated HF.