S1PR1 and psoriasis: Notablty, FTY720-P binds to S1P1, 3, 4, 5 and may result in multiple side effects; thus other selective S1P1 inhibitors (ONO-4641 and CS-0777) have been generated and undergone Phase 1 and 2 clinical trials for MS and psoriasis (reviewed in [125, 153]).