Malaria has been associated to gene selective pressure in the human genome, and it has been associated as an evolutionary force of some genetic diseases, such as sickle cell disease (SCD), thalassemia, glucose-6-phosphate dehydrogenase (G6PD) deficiency, and other red blood cell (RBC) genetic anemia with Mendelian inheritance. This evidence concerns the gene G6PD and G6PD deficiency.