However, in a large family and population-based association study, Malawi and Gambia showed that the effects of the four most common SNPs in the TLR9 gene, rs187084 (−1486C>T), rs5743836 (1237C>T), rs352139 (1174G>A), and rs352140 (2848G>A), were not associated with severe malaria [97]. This evidence concerns the gene TLR9 and malaria.