Proinflammatory Th1-type cytokines (IL-1, IL-6, IL-8, IL-12, IFN-gamma, and TNF-α) are critical for controlling the erythrocytic and hepatic stages of Plasmodium infection [6, 7], but the excessive production of these cytokines might also contribute to disease manifestations and/or tissue damage, such as the brain in cases of cerebral malaria. This evidence concerns the gene IFNG and cerebral malaria.