Consequently, adiponectin levels were lower in boys than that in girls during puberty, and the differences were significant at T2 (P < 0.01) and T3 (P < 0.05) in normal weight, T2 (P < 0.05) and T5 (P < 0.05) in overweight, and T3 (P < 0.01) in obesity group, respectively. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.