Similarly another long non-coding RNA, namely, Psoriasis susceptibility-related RNA Gene Induced by Stress (PRINS) has been shown to be upregulated following infection with the Herpes Simplex Virus (Sonkoly et al., 2005) and treatment with bacterial cell wall extracts (Bari et al., 2011) apart from other stress factors such as ultraviolet radiation, etc. Unbiased genome-wide associations have also implicated PRINS as a conspicuous factor in psoriasis (Sonkoly et al., 2005). The gene discussed is ENSG00000280371; the disease is psoriasis.