CD40LG and atherosclerosis: Moreover, immunization of cholesterol-fed atherosclerosis prone LDL receptor deficient (Ldlr-/-) mice with heat-killed extracts of R36a S. pneumoniae containing PC resulted in high anti-OxLDL IgM titers, which were found to be nearly all of the T15/E06 clonotype, and significantly reduced atherosclerotic plaque development (Binder et al., 2003).