After contact with RAE-1, the NKG2D receptor triggers activation of NK cell cytotoxicity-related molecules, TNF-related apoptosis-inducing ligand (TRAIL), perforin and FasL and therefore the induction of NK cell cytotoxicity toward tumor cells and the secretion of IFN-γ (Hou et al., 2009; Zhou et al., 2012). Here, TNFSF10 is linked to neoplasm.