Furthermore, Fc-FcγR interactions in NK cell mediated ADCC are important for the in vivo antitumor effects of the mAbs Rituximab (anti-CD20) for lymphomas, Herceptin (anti-Her2/neu) for breast cancers, Cetuximab (anti-EGFR) for head and neck cancer, and anti-GD2 for neuroblastomas (Clynes et al., 2000; Levy et al., 2011). This evidence concerns the gene ERBB2 and neuroblastoma.