There are many activating receptors, including the natural cytotoxicity receptors (NCRs; NKp30, NK40, NKp46), NKG2D, 2B4/CD244, CD2, LFA-1, co-receptors such as DNAM-1, and the Fc receptor CD16 (FcγRIIIa) that supports antibody-dependent cell-mediate cytotoxicity (ADCC) that is involved in many monoclonal antibody (mAb) anti-tumor therapies (Bottino et al., 2006; Schleinitz et al., 2008; Pegram et al., 2011). This evidence concerns the gene CD244 and neoplasm.