IFNG and neoplasm: •Downregulation of NKG2DL on K562 and CML tumor cells leading to reduced cytotoxicity and IFN-γ production (Salih et al., 2010) •Downregulation of ICMA-1 on BCR/ABL-transfected leukemic tumor cells accompanied by decreased cytotoxicity (Baron et al., 2002) •DC stimulation leading to increased NK cell activity in human and mice (Borg et al., 2004)