•Downregulation of NKG2D, NKp46, and NKp30 (Ogbomo et al., 2007; Rossi et al., 2012) •Inhibition of cytotoxicity toward various tumor cells (Ogbomo et al., 2007; Alvarez-Breckenridge et al., 2012) •Inhibition of cytokine production (Alvarez-Breckenridge et al., 2012; Rossi et al., 2012). The gene discussed is KLRK1; the disease is neoplasm.