•Increased NK cell numbers and activation in Raji-bearing SCID mice via stimulation by DCs and their cytokines (Reddy et al., 2008) •T cell stimulation leading to increased ADCC and cytotoxicity of NK cells toward K562 and MM tumor cells (Hayashi et al., 2005) •Upregulation of CD69 (Payvandi et al., 2005) •Increased IFN-γ production (Payvandi et al., 2005). This evidence concerns the gene CD69 and neoplasm.