•Downregulation of NKG2DL on K562 and CML tumor cells leading to reduced cytotoxicity and IFN-γ production (Salih et al., 2010) •Downregulation of ICMA-1 on BCR/ABL-transfected leukemic tumor cells accompanied by decreased cytotoxicity (Baron et al., 2002) •DC stimulation leading to increased NK cell activity in human and mice (Borg et al., 2004). Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.