MICA and cancer: Noteworthy, romidepsin-dependent upregulation of MICA/B on cancer cells showed an essential involvement of the glycogen synthase kinase-3, whereas the sodium butyrate-induced upregulation was influenced by increased binding of Sp1 together with heat shock transcription factor 1 to the MICA/B promotor (Skov et al., 2005; Zhang et al., 2009).