•Induction of inhibitory KIRs resulting in decreased cytotoxicity (Gao et al., 2009) •Downregulation of CD16, NKG2D, and NKp30 (Schmiedel et al., 2011) •Inhibition of cytotoxicity toward K562 and Raji tumor cells and cytokine production (Schmiedel et al., 2011). This evidence concerns the gene KLRK1 and neoplasm.