BCR and neoplasm: On side of the tumor, a direct control of the expression of the NKG2D ligands (NKG2DLs) MHC class I-related chain molecules (MIC)A/B by BCR/ABL has been shown and was reduced by different TKIs leading to decreased NK cell-mediated cytotoxicity and IFN-γ production (Boissel et al., 2006; Salih et al., 2010).