•Downregulation of NKp46 and NKp30 (Ogbomo et al., 2007) •Inhibition of cytotoxicity toward various tumor cells (Ogbomo et al., 2007; Anshelevich et al., 2010) •Inhibition of cytokine production (Rossi et al., 2012). This evidence concerns the gene NCR3 and neoplasm.