IKBKB and Insulin resistance: Indeed, the activation of IKKβ/NF-κB in hepatocytes-induced liver inflammation and insulin resistance (Arkan et al., 2005; Cai et al., 2005; Tamura et al., 2007; Wunderlich et al., 2008) and was associated with a reduced ability of insulin to suppress neoglucogenesis (Arkan et al., 2005) and with an increased production of VLDL leading to the development of hypertriglyceridemia (van Diepen et al., 2011).