It is recognized that IL-1β is one of the main cytokines implicated in the desensitization of insulin signaling (Lagathu et al., 2006; Jager et al., 2007) and its genetic invalidation protects mice against diet-induced insulin resistance (Stienstra et al., 2010; Wen et al., 2011). The gene discussed is INS; the disease is Insulin resistance.