Indeed, the activation of IKKβ/NF-κB in hepatocytes-induced liver inflammation and insulin resistance (Arkan et al., 2005; Cai et al., 2005; Tamura et al., 2007; Wunderlich et al., 2008) and was associated with a reduced ability of insulin to suppress neoglucogenesis (Arkan et al., 2005) and with an increased production of VLDL leading to the development of hypertriglyceridemia (van Diepen et al., 2011). The gene discussed is INS; the disease is Insulin resistance.