For example, mice with VMH-specific deletion of a number of genes including the leptin receptor (Dhillon et al., 2006; Bingham et al., 2008), estrogen receptor α (Musatov et al., 2006, 2007), and vesicular glutamate transporter-2 (VGLUT2; Tong et al., 2007) result in a number of abnormalities such as increased feeding, reduced energy expenditure, impaired glucose homeostatic regulation, and obesity. The gene discussed is SLC17A6; the disease is obesity due to melanocortin 4 receptor deficiency.