INS and Hypoglycemia: Though adult Ucn 3 KO mice fed a chow diet show no differences in glucose tolerance and insulin sensitivity compared to WT mice (Li et al., 2007), Ucn 3 KOs have lower basal insulin levels and show a greater rebound in blood glucose levels after the initial hypoglycemia during an insulin tolerance test (Li et al., 2007; Chao et al., 2012).