The perception is further supported by the evidence that transgenic murine pancreatic β-cells specifically overexpressing GCGR displayed enhanced glucose-competent insulin secretion, associated with increased β-cell mass and pancreatic insulin content, rendering the mice partially protected from high-fat diet feeding-induced hyperglycemia and impaired glucose tolerance (Gelling et al., 2009). The gene discussed is GCGR; the disease is Hyperglycemia.