Compiled data in literature have clearly shown that γδ T lymphocytes contribute to the development of IgE-mediated responses, enhancing eosinophil tissue accumulation and airway hyperresponsiveness (Zuany-Amorim et al., 1998; Lahn et al., 1999; Schramm et al., 2000; Svensson et al., 2003; Costa et al., 2010), whereas other reports have demonstrated that γδ T lymphocytes also suppress airway hyperresponsiveness and IgE production during in vivo models of allergic lung inflammation (McMenamin et al., 1994; Lahn et al., 1999). The gene discussed is IGHE; the disease is airway hyperresponsiveness.