TNF and obesity due to melanocortin 4 receptor deficiency: Adipose tissue actively participates in obesity-induced inflammation through recruitment of macrophages and T cells and release of inflammatory cytokines (monocyte chemotactic protein-1, MCP-1; tumor necrosis factor alpha, TNF-α; interleukin-6, IL-6) which modulate adipocyte differentiation, metabolism, and local/systemic inflammatory responses, causing undesirable metabolic imbalances [2, 4].