IGHE and allergic asthma: Other studies in severe persistent allergic asthma patients receiving omalizumab therapy have focused on modulation of serum soluble TNF-related apoptosis-inducing ligand, total antioxidant capacity, hydrogen peroxide, malondialdehyde and total nitric oxide concentrations, and ceruloplasmin oxidase activity measurements, as markers of the efficacy of anti-IgE treatment modality [43–46].