For instance, TAMs release potent proangiogenic cytokines such as IL-8 (or Cxcl8) and growth factors as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and TGF-β, which have been reported to promote angiogenesis in tumors such as gliomas, squamous cell carcinomas of the esophagus, and breast, bladder, and prostate carcinomas [59–63]. This evidence concerns the gene VEGFA and central nervous system cancer.