In fact, and in agreement with a recent report from Coleman et al. [42], we found that, although HIV-1 infection led to BST-2/tetherin up-regulation, viral spread from DC was not efficiently restricted in the presence of BST-2/tetherin, even after removal of the SAMHD1-mediated post-entry restriction block with Vpx. Here, BST2 is linked to HIV-1 infection.