As well as Mirk/Dyrk1B regulating cell cycle-related proteins cyclin D1 and p27kip1, it has been demonstrated that blocking mitogenic-activated protein kinase kinae (MEK) - extracellular signal-regulated kinase (ERK) signaling pathway increases Mirk abundance by up-regulating Mirk/Dyrk1B transcription in either myoblast or colon cancer cells [2], suggesting the possible involvement of mitogenic-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling in Mirk/Dyrk1B functions. The gene discussed is MAP2K7; the disease is colonic neoplasm.