The fact that several types of muscular disorders (e.g. malignant hyperthermia, central core disease, multi-minicore disease) result from either inherited or de novo mutations in the RYR1 gene underscores the critical role that proper RyR1 Ca2+ release channel function plays in coordinating skeletal muscle performance (for review, see [1]–[3]). Here, RYR1 is linked to Malignant hyperthermia.