Increased mRNA expression of IFN-γ TNF-α, IL-6, IL-8 and IL-12 in tuberculosis granuloma [47] and secretion of cytokines IL-1β, TNF-α and IL-6 in bronchoalveolar lavage fluid from involved sites of pulmonary TB have been reported [48]. This evidence concerns the gene CXCL8 and pulmonary tuberculosis.