[36]. In our in vitro granuloma model tgs1 deletion mutant showed compromised ability to go into dormancy There is evidence that lipY, the only known mycobacterial enzyme with long chain TG hydrolase activity, is involved in the utilization of stored TG in Mtb[62], [64]. It has been suggested that lipY is involved in mobilizing stored TG during reactivation. In our human granuloma model the lipY deficient Mtb demonstrated compromised ability to resuscitate upon immunosuppression with anti-TNFα antibody. This evidence concerns the gene TGS1 and Granuloma.