These laminins were strongly adhesive for KG1C glioma cells (OD values 1.48 and 1.39 for rhLM511 and rhLM521, respectively), BE melanoma cells (OD values 1.65 and 1.56 for rhLM511 and rhLM521, respectively) and MDA-MB-231 breast carcinoma cells (OD values 1.82 and 1.85 for rhLM511 and rhLM521, respectively), when compared to human serum albumin (HSA) (OD values 0.10, 0.10 and 0.09 for KG1C, BE and MDA-MB-231 cells, respectively) and the cell adhesion was largely mediated by β1 integrins, preferentially α3β1 and α6β1. The gene discussed is LAMB2; the disease is melanoma.