The post-transcriptional downregulation of m-Numb protein expression by canonical Msi1-Numb-Notch axis regulation [16] has been found in wild type cerebral tissue (Figure 3A), glioblastoma U251MG [27], leukemia cells [14], [15] and fibroblast NIH3T3 cells [11]. Here, NUMB is linked to glioblastoma.