Though these tumors are typically benign, NF2 loss has been implicated in the progression of many malignant tumors including highly aggressive mesothelioma tumors in humans [2], [3] and mice with heterozygous loss of NF2 are prone to the formation of multiple highly metastatic tumors, predominantly osteosarcomas and fibrosarcomas [4]. The gene discussed is NF2; the disease is osteosarcoma.