As shown in Table 3, no significant difference was detected for overall cancer risk between the insulin users and the non-insulin users (crude RR = 1.05, 95% CI 0.82–1.35, P = 0.695; fully adjusted: RR = 1.20, 95% CI 0.89–1.62, P = 0.228, Figure 2A). The gene discussed is INS; the disease is cancer.