CASP3 and Alzheimer disease: Activated caspase 3 has been implicated in multiple effects seen in AD, including GGA3 cleavage, which is required for BACE lysosomal degradation [27], the PI3k-Akt/mTOR pathway which regulates Aβ oligomer induced neuronal cell cycle events [28] and tau hyperphosphorylation, which cleaves tau and initiates/or accelerates tau pathology [29].