DNMT1 and Alzheimer disease: For example, nuclear loss and cytoplasmic sequestering of DNMT1 has been linked to increased α-synuclein in Parkinson’s disease, Lewy body disease, and α-synuclein transgenic mice [17], and has been suggested to underlie global DNA hypomethylation in affected neurons similar to that which we previously reported in AD [12], [18].