The insulin dosage was reduced by approximately 70% (T2D-HF: 60±31 IE vs. 20±11 IE, p<0.001; T2D-nonHF: 61±14 IE vs. 14±11 IE, p<0.001) in each study group during hyperglycemia 24 hours before the investigations as compared with normoglycemia. Here, INS is linked to Hyperglycemia.