Importantly, according to our predictions, to achieve an annual testing rate of 20% will allow diagnosis of 90% of HIV-positive individuals within the first 8 years of infection, which in turn, and based on our previous predictions, will minimize mortality rate, maximize life expectancy and achieve diagnosis in a clinical stage where early mortality at initiation of treatment can be prevented by treatment strategies based on higher CD4 thresholds. The gene discussed is CD4; the disease is infection.