These 29 patients included 19 with a complete HP deficiency and 10 with a GH deficiency associated with other deficiencies, including TSH (n = 4), TSH and ACTH (n = 3), TSH and gonadotropin deficiencies (n = 1, associated with primary testicular deficiency) and amenorrhea (n = 2). The gene discussed is POMC; the disease is amenorrhea.