H2AX and malignant colon neoplasm: It has also been demonstrated that Frondanol A5, an impure extract of Cucumaria frondosa skin from which Frondoside A is originally derived, induced growth inhibition at S and G2-M phase with a decrease in Cdc25c and an increase in p21WAF1/CIP1 with significant apoptosis associated with H2AX phosphorylation and caspase-2 cleavage in the colon cancer-derived HCT116 cells [4].