Other examples of direct MYCN targets located within amplified regions in both our data set and previously reported array CGH data sets include CDK4 (in one MYCN amplified and one MYCN non-amplified tumor and two MYCN amplified cell lines) and MDM2 (in two MYCN amplified tumors and two MYCN amplified cell lines) [23], [26]. This evidence concerns the gene CDK4 and neoplasm.