Apart from the frequently occurring (large) DNA copy number alterations such as 17q gains and 1p, 3p and 11q deletions, the discoveries of rare focal genomic imbalances targeting ALK and NF1[5]–[10] and more recently also several genes implicated in neuritogenesis [11] have shown that such focal DNA copy number alterations mark important genes involved in neuroblastoma pathogenesis. The gene discussed is ALK; the disease is neuroblastoma.