The role of RNF11 in the TGFβ pathway is of particular interest in neuroblastoma given our previous finding that the miR-17∼92 cluster components target TGFBR2 and SMAD2 as well as TGFβ downstream regulated genes CDKN1A, ITGA4, and SERPINE1[12]. This evidence concerns the gene SERPINE1 and neuroblastoma.