We therefore hypothesize that miR-17∼92 copy number gain may have been selected to reinforce the MYCN-driven oncogenic phenotype in this cell line as this miRNA cluster is a well-established direct oncogenic target of MYCN and MYC and is consistently up regulated in MYCN/MYC amplified neuroblastoma as well as in other tumor entities [18], [41]. Here, MYCN is linked to neuroblastoma.