EP300 and cancer: Since the interaction of β-catenin with CBP promotes proliferation and maintenance of potency, while its interaction with p300 promotes the initiation of differentiation of embryonic and cancer stem cells [31], [48], β-catenin may bind predominantly to CBP during early hepatogenesis to promote the proliferation of hepatoblasts, while during the later stages of hepatogenesis, it may preferentially partner with p300 to regulate hepatocyte or biliary differentiation of hepatoblasts.