Emami et al previously showed that ICG-001 selectively binds the N-terminus of CBP, without binding to the highly homologous co-activator p300, leading to inhibition of proliferation and induction of apoptosis of a colon carcinoma cell line in part via decreased expression of Cyclin D1 and Survivin, an anti-apoptotic gene [38]. The gene discussed is CREBBP; the disease is colon carcinoma.