In this study, we demonstrate that FGF7 and FGF10, likely through FGFR2IIIb, induce downstream β-catenin activation and its nuclear translocation in both post-liver bud embryonic hepatoblasts and Mat1a−/− tumor initiating stem cell line via AKT-dependent phosphorylation of Serine-552. The gene discussed is FGF7; the disease is neoplasm.