Evidence obtained in non-TB diseases argue B-cells favor Th1 polarization (involved in TB protective immunity) through IL-6 and IFN-γ production during Salmonella infection, or promote Th2 differentiation (thought to be detrimental during TB) through either IL-2 (Wojciechowski et al., 2009) or IL-10 (Ferru et al., 1998; Popi et al., 2008; Ronet et al., 2010) in the control of different parasites. Here, IL10 is linked to Salmonella Infections.