Indeed, genetic deletion of AGT, ACE, renin, AT1, or AT2 protects rodents from diet-induced obesity and insulin resistance (Massiera et al., 2001b; Yvan-Charvet et al., 2005; Takahashi et al., 2007; Jayasooriya et al., 2008). The gene discussed is AGT; the disease is obesity due to melanocortin 4 receptor deficiency.