FOXP2 and Cognitive impairment: One notable exception to the candidate region approach was a genome wide linkage analysis in a family with a particularly severe form of verbal and oral motor apraxia (i.e., affecting both speech and non-speech oral movements) in the presence of impaired language comprehension and formulation, cognitive deficits, and differences in brain structures (Fisher et al., 1998); this analysis identified a mutation in FOXP2 as the cause for the autosomal dominant disorder (Lai et al., 2001).