In contrast, both mRNA as well as protein levels of leucine zipper transcription factor TSC22D4 were found to be induced in livers of tumour-bearing, cachectic mice as compared with healthy control littermates (Fig 3B, Supporting Information Fig S2A), demonstrating that tumour-associated energy wasting is tightly and specifically associated with elevated TSC22D4 expression in the liver. Here, TSC22D4 is linked to neoplasm.