TSC22D1 and neoplasm: Indeed, TSC22 family members have been shown in Drosophila to be part of a growth-promoting signaling complex involving the Mlf1 adapter molecule Madm (Gluderer et al, 2010), and a TSC22D1/D4 complex has been implicated in BRAF-induced senescence and neoplasia (Homig-Holzel et al, 2011).