Although Kaplan–Meier analysis and log-rank tests revealed that the all of the immune cells were significantly associated with OS and DFS duration, Cox multivariate analysis demonstrated that only the density of CD33+/p-STAT1+ cells within the cancer tissue was a prognostic factor for OS and DFS, independently, indicating that CD33+/p-STAT1+ cells play a key role in the regulation of the local immune response. This evidence concerns the gene CD33 and cancer.