Multivariate analyses showed that low expression of NDRG2 (P < 0.001), depth of invasion ≥pT3 (P < 0.001), distant organ metastasis (pM1) (P < 0.001), regional lymph node metastasis (≥pN1) (P < 0.001), and vascular invasion (Yes) (P = 0.008) were independent, poor prognostic factors of lung cancer; However, age (≥65 years), gender (male), tumor size, tumor grade, and histological type (>G2) were not related to the prognosis of lung cancer (see Table 2). The gene discussed is NDRG2; the disease is neoplasm.