LTA rs915654 minor A allele carriers and TNF-α rs1800629 major G allele homozygotes had increased MetS risk (OR 1.37 and OR 1.35). Possession of the IL-6 rs1800797 GG genotype by the LTA and TNF-α “risk genotype” carriers further increased MetS risk (OR 2.10). Low total PUFA/SFA exacerbated MetS risk (OR 4.4). Here, IL6 is linked to metabolic syndrome.