Previous studies have demonstrated the influence of a variety of pro-inflammatory cytokine polymorphisms, including tumor necrosis factor alpha (TNFα) (rs1800629) and interleukin 6 (IL-6) (rs1800795 and rs1800797) in the risk of central obesity, diabetes and MetS phenotypes [85,86,87,88,89]. This evidence concerns the gene IL6 and Abdominal obesity.