In the LIPGENE-SU.VI.MAX study we identified a number of novel associations between SNPs of genes involved in fatty acid and lipoprotein metabolism, including long-chain acyl CoA synthetase 1 (ACSL1), acetyl-CoA carboxylase β (ACC2), apolipoprotein A-I (APOA1) and apolipoprotein B (APOB) and lipoprotein lipase (LPL) with risk of the MetS or its phenotypes [81,82,83,84]. The gene discussed is APOB; the disease is metabolic syndrome.