In the LIPGENE-SU.VI.MAX study, the ApoB rs512535 and ApoA1 rs670 major G allele homozygotes had increased MetS risk (OR 1.65 and OR 1.42, respectively), which may be explained by their increased abdominal obesity and impaired insulin sensitivity but not dyslipidemia [84]. Here, INS is linked to Abdominal obesity.