DC trans-infection of CD4+ T cells appears to be dependent on interaction with the HIV Env, as DC-mediated transfer to CD4-expressing reporter cells was inhibited by the glycan-dependent anti-HIV-1 Env mAb 2 G12, as well as a CD4-inducible HIV-neutralizing mAb isolated from colostrum B cells CH08 [40] (Mean Percent Inhibition (M.P.I) of 80.0 and 39.9%, respectively) relative to an irrelevant anti-RSV mAb, Synagis (Figure 3A). This evidence concerns the gene CD4 and infection.