TRPV1 and colitis: Knockout of TRPV1 gene changed several important physiological characteristics of bladder function including prolonged intermicturition interval along with reduced urodynamic responses during active colitis in genetically modified mice; up-regulation of DSM contractility in response to KCl in TRPV1−/− mice with inflamed colon; diminished relaxation of DSM in transgenic animals in the presence of ROK inhibitor, and attenuated effects of colonic inflammation on VGSC in bladder sensory neurons.