TRPV1 and inflammation: The major differences included prolonged intermicturition interval in KO animals followed by reduced urodynamic responses during active colitis; up-regulation of DSM contractility in response to KCl in TRPV1−/− mice with inflamed colon; diminished relaxation of DSM in transgenic animals in the presence of ROK inhibitor; attenuated effects of colonic inflammation on expression and function of VGSC in bladder sensory neurons from TRPV1−/− mice; and delayed development of abdominal hypersensitivity upon colon-bladder cross-talk in genetically modified animals.