TRPV1 and colitis: However, in TRPV1−/− neurons, acute colitis induced a rightward shift in steady-state inactivation by 7 mV (V1/2 = −39.7 ± 1.9 mV in the vehicle group vs −32.7 ± 1.7 mV in TNBS group, P ≤0.05, Figure6D).