More importantly, our in vivo study revealed that intramyocardial injection of Txnip siRNA significantly decreased Txnip expression and thus effectively reduced myocardial infarct size and apoptosis in hyperglycaemia-treated I/R hearts, confirming the critical role of Txnip in hyperglycaemia-aggravated MI/R injury. The gene discussed is TXNIP; the disease is myocardial infarction.