Huang et al. [191] described the case of a de novo mutation in SCN5A (S1333Y) identified in an SIDS victim who also carried a T20I mutation in KCNE1. Priori et al. [192] reported on two cases of SIDS in a family with BrS and the L567Q mutation in SCN5A, which was later functionally characterized as a loss-of-function mutation by Wan et al. [193]. The gene discussed is KCNE1; the disease is sudden infant death syndrome.