SCN5A and familial long QT syndrome: In 2000, a “proof of concept” of cardiac ion channel mutations as a possible cause of SIDS was provided with the aforementioned description by Schwartz et al. [179] of an infant who was resuscitated from ventricular fibrillation and in whom LQTS was diagnosed and a de novo missense mutation in SCN5A (S941N) was identified.