Mutations in the sodium channel gene SCN5A, for example, have been assessed in the studies by Ackerman et al. [182], Wedekind et al. [196], Plant et al. [197], Arnestad et al. [199], Otagiri et al. [202], and Millat et al. [203], yielding a total of 542 SIDS cases, in which 28 mutations in SCN5A were detected (5.2%), almost all with functional significance (26, or 4.8%). The gene discussed is SCN5A; the disease is sudden infant death syndrome.