Thus far, mutations in three genes have been linked to CPVT, autosomal dominant mutations in the RYR2 gene encoding for the cardiac ryanodine receptor isoform 2 (CPVT type 1 or CPVT1) and rare autosomal recessive mutations in the CASQ2 and TRDN genes, encoding for the cardiac calsequestrin isoform 2 (CPVT2) and the triadin protein, respectively. This evidence concerns the gene TRDN and catecholaminergic polymorphic ventricular tachycardia.