It may even be higher, given that conventional genetic analysis may fail to uncover severe mutations [238–242] and that the determination of associations between SIDS and mutations in ion channel-related genes is still an emerging field, with several associations that have only recently been reported [206–208] and others that remain to be assessed, for example, a possible association between SIDS and mutations in the L-type calcium channel-related genes CACNA1C, CACNB2b, and CACNA2D1, which have been associated with LQTS, BrS, and SQTS (Table 1–3). This evidence concerns the gene CACNA2D1 and Familial short QT syndrome.