Concerning the histopathological characteristics of the breast cancer patients, elevated NLR, PLR, LPLR, d-dimers, and platelet-large cell ratio were significantly correlated with larger tumor size (P < 0.05 for all the parameters), while, regarding the positivity for HER2/neu overexpression, only LPLR and d-dimers were statistically significantly increased in the group of patients with positive staining (n = 8), compared to the patients with absence or moderate expression of HER2/neu (n = 27). This evidence concerns the gene ERBB2 and breast cancer.