Despite the fact that we did not assess directly the effect of our modification on the enhancement of the predictive value of PLR, as we did not correlate it with survival rates, it is evident that LPLR was correlated with all the standard predictors of survival in breast cancer-tumor stage, number of infiltrated lymph nodes, infiltrated/retrieved lymph node ratio, HER2/neu overexpression, and primary tumor size. The gene discussed is ERBB2; the disease is neoplasm.