In another study [56], feeding Otsuka Long-Evans Tokushima Fatty (OLEFT) rats, a model for type 2 diabetes in rats, with GBR or WR for 31 weeks showed that GBR could reduce levels of glycated hemoglobin A1c (HbA1c), tumor necrosis factor alpha, and PAI-1. Here, SERPINE1 is linked to type 2 diabetes mellitus.