As shown in Figure 5(g), cleaved caspase-3 positive cells were significantly increased in the cortex and hippocampus CA1 to CA3 (P < 0.001), and treatment with GFW 2.0 g/kg could decrease hyperglycemia-induced cleaved caspase-3 positive cells in the cortex and hippocampus CA1, CA2 and CA3 (P < 0.05). Here, CASP3 is linked to Hyperglycemia.