In a recent study, the frequency of anti-Ro52 antibodies was similar to that of anti-Ro60 in all groups but the myositis (35.4% versus 0.0%, P < 0.001) and SSc (19.0% versus 6.0%, P < 0.005) cohorts using the consensus of three different laboratory methods [15]. Here, TRIM21 is linked to systemic sclerosis.