While anti-Ro/SSA antibodies are primarily found in patients with SLE and SS, they are also sometimes seen in other systemic autoimmune diseases, such as systemic sclerosis (SSc), polymyositis/dermatomyositis (PM/DM), mixed connective tissue disease (MCTD), and rheumatoid arthritis (RA) [15, 16]. This evidence concerns the gene TRIM21 and mixed connective tissue disease.